After you have perhaps spent years laboring over your beloved novel and are seeking publication, do yourself a favor and FOLLOW THE SUBMISSION RULES clearly stated on the publisher’s website. If it says you may send a query letter, but please do not send unsolicited manuscripts, then guess what Einstein, emailing a copy of the manuscript is going to accomplish one thing – making the publisher pissed off at you for not heeding the clearly stated warning. Not only will he NOT read your manuscript, he will be disinclined to consider your work if you should properly query him later. Those following the rules will have their query letters carefully considered, and (A) be invited to submit a sample of the work or (B) get a very polite letter in return explaining why their work is not right for the publisher. Not following the rules will result in NO REPLY to your submission and a ranty blog post on Live Journal.
There, I feel better now.